Depuis plus de 20 ans, Helixio contribue à des projets d’envergure en génomique, transcriptomique et bioinformatique. Forte de cette expérience, l'équipe scientifique d'Helixio sait que chaque projet est unique. Nos plateformes, localisées sur le biopôle Clermont-Limagne près de Clermont-Ferrand, prennent en charge des échantillons complexes, y compris lorsque les quantités d'ADN ou d'ARN disponibles sont limitées.
Nous proposons nos services à des laboratoires privés, universitaires et industriels, basées sur la technologie NGS (séquençage de nouvelle génération). Nous pouvons également vous aider à développer des solutions génomiques personnalisées et prendre en charge l’analyse bioinformatique de vos projets. Nous adaptons nos workflows à vos besoins car notre objectif est d’interpréter de manière efficace et didactique vos données génomiques.
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Notre expertise : Sélection de quelques publications
2026
SSRN (2026)
Mitochondrial-targeting fungicide formulations exacerbate the effects of Nosema ceranae infection in the honeybee Apis mellifera
Gilbert J, Mathien C, Portelli C, Courtine D, Bonmatin J-M, Huc L, El Alaoui H, Diogon M, Delbac F
Gut Microbes (2026)
EB1010, a putative Christensenellaceae-derived microbial peptide, exhibits anti-inflammatory activity and therapeutic potential in ulcerative colitis
Orsini Delgado ML, Baudesson de Chanville C, Pfister H, Bardouillet L, Farin W, Rinaudo P, Quessel J, Strozzi F, Pereira H, Maresca M, Nicoletti C, Di Pasquale E, Mailhac C, Thomas V, Blum S, Chevalier G, Toussaint H, Luangsay S, Bonny C, Chene L, Cultrone A
Preprint medRxiv (2026)
Transcriptomic Immune-related Signature Predictive of Chemoradiotherapy Response in Anal Squamous Cell Carcinoma
Iseas S, Golubicki M, Lacunza E, Prost D, Bouchereau S, Lahaie C, Baba-Hamed N, Raymond N, Adam J, Carlos Abba M
Scientific Reports (2026)
Staphylococcus aureus derived extracellular vesicles modulate osteoblast-like cell immune responses independently of vesicle internalization
Papail J, Daniel N, Prado L, Vassaux D, Péron S, Even C, Lebret V, Silva Rosa Da Luz B, Le Gouar Y, Jardin J, Berkova N, de Castro Soares S, Yoshida K-I, Azevedo V, Chabelskaya S, Le Loir Y, Guédon É
Journal of Experimental Botany (2026)
Natural variation in Arabidopsis uncouples leaf and flower development and reveals massive transcriptomic heterochrony
Dieudonné S, Kristianingsih R, Hallet S, Jesson B, Vidal V, Wells R, Morris RJ, Besnard F
Current Research in Parasitology & Vector-borne Diseases (2026)
Exploration of geographical population structure of Anaplasma phagocytophilum: Insights from 12 newly sequenced European human and bovine genome assemblies
Rouxel C, Deshuillers PL, Vila-Nova M, Merda D, Boyer P, Jaulhac B, Saegerman C, Delooz L, Kuntz G, Boulouis H-J, Haddad N, Lagrée A-C, Chesnai V
Preprint bioRxiv (2026)
Functional divergence of regulatory and conventional bovine neutrophils following Mycobacterium bovis infection
Saint-Vanne M, Bounab B, Eymieux S, Perdriau E, Carerras F, Roullier R, Le Vern Y, Pichon J, Doz-Deblauwe E, Germon P, Winter N, Remot A
NAR Molecular Medicine (2026)
Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway
Bouchereau W, Chenane L, Weiss-Gayet M, Lessard L, Cardona Y, Mounier R, Gallay L, Allenbach Y, Benveniste O, Corpet A, Chazaud B, Lomonte P
2025
OncoImmunology (2025)
Systematic identification of lincRNA-derived immunogenic peptides in melanoma
Dupré E, Guiho A, Beauvais T, Labous L, Cardon T, Bertolotto C, Khammari A, Quéreux G, Salzet M, Labarrière N, Rabu C & Lang F
Journal of Experimental & Clinical Cancer Research (2025)
The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse
Muylaert C, Van Hemelrijck LA, Van der Vreken A, Heestermans R, Satilmis H, Verheye E, Alaterre E, Olsen C, De Beule N, De Veirman K, Menu E, Vanderkerken K, Moreaux J, De Bruyne E
BMC Genomics (2025)
Transcriptomic analysis of the interactions between Fibrobacter succinogenes S85, Selenomonas ruminantium PC18 and a live yeast strain used as a ruminant feed additive
Desvignes P, Ruiz P, Guillot L, Danon J, Durand A, Beaumont M, Chaucheyras-Durand F, Forano E
Virology (2025)
Coding-complete genome sequences of hedgehog coronavirus isolated from Erinaceus europaeus in France
Beissat K, Picard-Meyer E, Arné P, Chanteclair F, Le Barzic C, Hivert L, Le Loc'h G, Puech M-P, Bastien F, Schereffer J-L, Wasniewski M
npj Vaccines (2025)
Characterization of a suspension Vero cell line for viral vaccine production
Bourigault L, Bresson C, Jean C, Chevalard C, Kloutz M, Soulet D, Pelissier F, Richard S, Bassard I, Sève N, Charretier C, Pain B
Environmental Pollution (2025)
Environmental exposure to endocrine disruptors induces insulin resistance and hepatic inflammation in adult male rats, with partial transmission across subsequent generations
Darracq-Ghitalla-Ciock M, Rajkumari N, Veyrenc S, Chuffart F, Attia S, Hiriart-Bryant E, Vial G, Rangarajan S, Tubbs E, Raveton M, Fontaine E, Guillemain I, Dubouchaud H, Schlattner U, Tokarska-Schlattner M, Couturier K, Reynaud S
Molecular Reproduction and Development (2025)
Establishment and Characterization of Bovine Trophoblast Stem Cells Growing as Adherent Cells or Vesicles
Baquerre C, Delahaye A, Brochard V, Nuttinck F, Jean C, Robert E, Kress C, Rival-Gervier S, Pain B, Jouneau A
Preprint HAL (2025)
Multimodal integration of data characterizing the evolution of the gutbrain axis during the prodromal phase of Parkinson’s disease in a rat model
Hamadache M, Mouton L, Barriere D, Keller C, Chassain C, Pages G, Delhomme C, Bernalier A, Bonny J-M, Racoceanu D
Journal of Extracellular Biology (2025)
Extracellular Vesicles From Follicular Fluid in Infertile Women: Size, Morphology and miRNA Content Analysis
Ducarre S, Chiechio RM, Moulin G, Butera E, Dupont A, Penno C, El Amrani A, Heichette C, Even-Hernandez P, Marchi V, Ravel C
Cellular and Molecular Life Sciences (2025)
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
Picard F, Nonaka T, Belotti E, Osseni A, Errazuriz-Cerda E, Jost-Mousseau C, Bernard E, Conjard-Duplany A, Bohl D, Hasegawa M, Raoul C, Galli T, Schaeffer L, Leblanc P
NAR Genomics and Bioinformatics (2025)
Cluefish: mining the dark matter of transcriptional data series with over-representation analysis enhanced by aggregated biological prior knowledge
Franklin E, Billoir E, Veber P, Ohanessian J, Delignette-Muller M-L, Prud'homme SM
2024
Epigenetics & Chromatin (2024)
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
Kress C, Jouneau L, Pain B
OncoImmunology (2024)
FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population
Constantinides M, Robert N, Multrier C, Coënon L, Campos-Mora M, Jacquard C, Gao F, Zemiti S, Presumey J, Cartron G, Moreaux J, Villalba M
Gut Pathogens (2024)
Exploring the impact of digestive physicochemical parameters of adults and infants on the pathophysiology of Cryptosporidium parvum using the dynamic TIM-1 gastrointestinal model
Tottey J, Etienne-Mesmin L, Chalançon S, Sausset A, Denis S, Mazal C, Blavignac C, Sallé G, Laurent F, Blanquet-Diot S, Lacroix-Lamandé S
Bacteriology (2024)
FabR, a regulator of membrane lipid homeostasis, is involved in Klebsiella pneumoniae biofilm robustness
Dramé I, Rossez Y, Krzewinski F, Charbonnel N, Ollivier-Nakusi L, Briandet R, Dague E, Forestier C, Balestrino D
Malaria Journal (2024)
The impact of agrochemical pollutant mixtures on the selection of insecticide resistance in the malaria vector Anopheles gambiae: insights from experimental evolution and transcriptomics
Sadia CG, Bonneville J-M, Zoh MG, Fodjo BK, Kouadio F-PA, Oyou SK, Koudou BG, Adepo-Gourene BA, Reynaud S, David J-P, Mouhamadou CS
Cell Reports (2024)
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
Geraud M, Cristini A, Salimbeni S, Bery N, Jouffret V, Russo M, Ajello AC, Fernandez Martinez L, Marinello J, Cordelier P, Trouche D, Favre G, Nicolas E, Capranico G, Sordet O
Preprint bioRxiv (2024)
Epigenenomic and transcriptomic characterization of NPM1-mutated CN-AML subtypes
N’Guyen L, Tellez-Quijorna C, Vernerey J, Garciaz S, Carbuccia N, Guille A, Burny C, Poplineau M, Murati A, Hospital M-A, Vey N, Birnbaum D, Duprez E
Virology (2024)
High pathogenicity avian influenza A (H5N1) clade 2.3.4.4b virus infection in a captive Tibetan black bear (Ursus thibetanus): investigations based on paraffin-embedded tissues, France, 2022
Bessière P, Gaide N, Croville G, Crispo M, Fusade-Boyer M, Abou Monsef Y, Dirat M, Beltrame M, Dendauw P, Lemberger K, Guérin J-L, Le Loc'h G
Proceedings of the National Academy of Sciences (2024)
The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes
Roubille S, Escure T, Juillard F, Corpet A, Néplaz R, Binda O, Seurre C, Gonin M, Bloor S, Cohen C, Texier P, Haigh O, Pascual O, Ganor Y, Magdinier F, Labetoulle M, Lehner PJ, Lomonte P
2023
Nutrients (2023)
Circulating Human Metabolites Resulting from TOTUM-070 Absorption (a Plant-Based, Polyphenol-Rich Ingredient) Improve Lipid Metabolism in Human Hepatocytes: Lessons from an Original Ex Vivo Clinical Trial
F. Wauquier, L. Boutin-Wittrant, S. Krisa, J. Valls, C. Langhi, Y. F. Otero, P. Sirvent, S. Peltier, M. Bargetto, M. Cazaubiel, V. Sapone, A. Bouchard-Mercier, V. Roux, N. Macian, G. Pickering, Y. Wittrant
Animal Microbiome (2023)
Effects of rearing mode on gastrointestinal microbiota and development, immunocompetence, sanitary status and growth performance of lambs from birth to two months of age
Dunière L, Ruiz P, Lebbaoui Y, Guillot L, Bernard M, Forano E, Chaucheyras-Durand F
Frontiers in Oncology (2023)
Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma
Bruyer A, Dutrieux L, de Boussac H, Martin T, Chemlal D, Robert N, Requirand G, Cartron G, Vincent L, Herbaux C, Lutzmann M, Bret C, Pasero P, Moreaux J, Ovejero S
Research in Microbiology (2023)
Diversity of ethanolamine utilization by human commensal Escherichia coli
Moreira de Gouveia MI, Daniel J, Garrivier A, Bernalier-Donadille A, Jubelin G
PLOS Neglected Tropical Diseases (2023)
Whole genome sequencing and phylogenetic characterisation of rabies virus strains from Moldova and north-eastern Romania
Dascalu MA, Picard-Meyer E, Robardet E, Servat A, Arseniev S, Groza O, Starciuc N, Vuta V, Barbuceanu F, Tanase OI, Daraban Bocaneti F, Quenault H
Malaria Journal (2023)
Deltamethrin and transfluthrin select for distinct transcriptomic responses in the malaria vector Anopheles gambiae
Gonse Zoh M, Bonneville J-M, Laporte F, Tutagata J, Sadia CG, Fodjo BK, Mouhamadou CS, McBeath J, Schmitt F, Horstmann S, Reynaud S, David J-P
Cells (2023)
NLRP7 Enhances Choriocarcinoma Cell Survival and Camouflage in an Inflammasome Independent Pathway
Reynaud D, Alfaidy N, Collet C, Lemaitre N, Sergent F, Miege C, Soleilhac E, Al Assi A, Murthi P, Courtois G, Fauvarque M-O, Slim R, Benharouga M, Abi Nahed R
Journal of Travel Medicine (2023)
Climate change and vector-borne diseases: a multi-omics approach of temperature-induced changes in the mosquito
Bellone R, Lechat P, Mousson L, Gilbart V, Piorkowski G, Bohers C, Merits A, Kornobis E, Reveillaud J, Paupy C, Vazeille M, Martinet J-P, Madec Y, De Lamballerie X, Dauga C, Failloux A-B
Peer Community Journal (2023)
Expression of cell-wall related genes is highly variable and correlates with sepal morphology
Hartasánchez DA, Kiss A, Battu V, Soraru C, Delgado-Vaquera A, Massinon F, Brasó-Vives M, Mollier C, Martin-Magniette M-L, Boudaoud A, Monéger F
Cancer (2023)
The STEMRI trial: Magnetic resonance spectroscopy imaging can define tumor areas enriched in glioblastoma stem-like cells
Lemarié A, Lubrano V, Delmas C, Lusque A, Cerapio J-P, Perrier M, Siegfried A, Arnauduc F, Nicaise Y, Dahan P, Filleron T, Mounier M, Toulas C, Cohen-Jonathan Moyal E
Nutrients (2023)
Totum-070, a Polyphenol-Rich Plant Extract, Prevents Hypercholesterolemia in High-Fat Diet-Fed Hamsters by Inhibiting Intestinal Cholesterol Absorption
Langhi C, Vallier M, Otero YF, Maura M, Le Joubioux F, Groult H, Achour O, Budhi Pebriana R, Giera M, Guigas B, Maugard T, Chassaing B, Peltier S, Bard J-M, Sirvent P
International Journal of Molecular Sciences (2023)
Deciphering the Cardiovascular Potential of Human CD34+ Stem Cells
Aries A, Zanetti C, Hénon P, Drénou B, Lahlil R
Particle and Fibre Toxicology (2023)
Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life
Carlé C, Boucher D, Morelli L, Larue C, Ovtchinnikova E, Battut L, Boumessid K, Airaud M, Quaranta-Nicaise M, Ravanat J-L, Dietrich G, Menard S, Eberl G, Barnich N, Mas E, Carriere M, Al Nabhani Z, Barreau F
2022
Theranostics (2022)
Comprehensive Characterization of the Epigenetic Landscape in Multiple Myeloma
E. Alaterre, S. Ovejero, L. Herviou, H. de Boussac, G. Papadopoulos, M. Kulis, S. Boireau, N. Robert, G. Requirand, A. Bruyer, G. Cartron, L. Vincent, A. M. Martinez, J. Ignacio Martin-Subero, G. Cavalli, J. Moreaux
PeerJ (2022)
Transcriptome profiling reveals stress-responsive gene networks in cattle muscles
Cassar-Malek I, Pomiès L, de la Foye A, Tournayre J, Boby C, Hocquette J-F
Frontiers in Immunology (2022)
miRNA profile at diagnosis predicts treatment outcome in patients with B-chronic lymphocytic leukemia: A FILO study
Duroux-Richard I, Gagez A-L, Alaterre E, Letestu R, Khalifa O, Jorgensen C, Leprêtre S, Tchernonog E, Moreaux J, Cartron G, Apparailly F
Frontiers in Immunology (2022)
The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance
Ovejero S, Viziteu E, Dutrieux L, Devin J, Lin Y-L, Alaterre E, Jourdan M, Basbous J, Requirand G, Robert N, de Boussac H, Seckinger A, Hose D, Vincent L, Herbaux C, Constantinou A, Pasero P, Moreaux J
Genes (2022)
Genetic Profile of Patients with Limb-Girdle Muscle Weakness in the Chilean Population
Cerino M, González-Hormazábal P, Abaji M, Courrier S, Puppo F, Mathieu Y, Trangulao A, Earle N, Castiglioni C, Díaz J, Campero M, Hughes R, Vargas C, Cortés R, Kleinsteuber K, Acosta I, Urtizberea JA, Lévy N, Bartoli M, Krahn M, Jara L, Caviedes P, Gorokhova S, Bevilacqua JA
eLife (2022)
Physiological TLR4 regulation in human fetal membranes as an explicative mechanism of a pathological preterm case
Belville C, Ponelle-Chachuat F, Rouzaire M, Gross C, Pereira B, Gallot D, Sapin V, Blanchon L
Environmental Pollution (2022)
Exposure to a mixture of benzo[a]pyrene and triclosan induces multi-and transgenerational metabolic disorders associated with decreased female investment in reproduction in Silurana (Xenopus) tropicalis
Usal M, Veyrenc S, Darracq-Ghitalla-Ciock M, Regnault C, Sroda S, Fini J-B, Raveton M, Reynaud S
2021
BMC Genomics (2021)
The Molecular Signatures of Compatible and Incompatible Pollination in Arabidopsis
C. Kodera, J. Just, M. Da Rocha, A. Larrieu, L. Riglet, J. Legrand, F. Rozier, T. Gaude, I. Fobis-Loisy
npj Breast Cancer (2021)
Recurrence biomarkers of triple negative breast cancer treated with neoadjuvant chemotherapy and anti-EGFR antibodies
Radosevic-Robin N, Selenica P, Zhu Y, Won HH, Berger MF, Ferrando L, Cocco E, Privat M, Ponelle-Chachuat F, Abrial C, Nabholtz J-M, Penault-Llorca F, Reis-Filho JS, Scaltriti M
Autophagy (2021)
Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia
Thiebaut AM, Buendia I, Ginet V, Lemarchand E, Boutagouga Boudjadja M, Hommet Y, Lebouvier L, Lechevallier C, Maillasson M, Hedou E, Déglon N, Oury F, Rubio M, Montaner J, Puyal J, Vivien D, Roussel BD
Journal of Personalized Medicine (2021)
RNA-Sequencing-Based Transcriptomic Score with Poor Prognostic and Theranostic Values in Multiple Myeloma
E. Alaterre, V. Vikova, A. Kassambara, A. Bruyer, N. Robert, G. Requirand, C. Bret, C. Herbaux, L. Vincent, G. Cartron, O. Elemento, J. Moreaux
Cancers (2021)
DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia Model
B. Lebecque, C. Bourgne, V. Vidal, M. G. Berger
Immunobiology and Immunotherapy (2021)
Plasmablasts derive from CD23– activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction
Pignarre A, Chatonnet F, Caron G, Haas M, Desmots F, Fest T
Leukemia (2021)
RNA-sequencing data-driven dissection of human plasma cell differentiation reveals new potential transcription regulators
Kassambara A, Herviou L, Ovejero S, Jourdan M, Thibaut C, Vikova V, Pasero P, Elemento O & Moreaux J
Aquatic Toxicology (2021)
Molecular bases of P450-mediated resistance to the neonicotinoid insecticide imidacloprid in the mosquito Ae. aegypti
Gonse Zoh M, Gaude T, Prud'homme SM, Riaz MA, David J-P, Reynaud S
Environmental Pollution (2021)
Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis
Usal M, Veyrenc S, Darracq-Ghitalla-Ciock M, Regnault C, Sroda S, Fini J-B, Canlet C, Tremblay-Franco M, Raveton M, Reynaud S
Scientific Reports (2021)
Experimental evolution supports the potential of neonicotinoid-pyrethroid combination for managing insecticide resistance in malaria vectors
Gonse Zoh M, Bonneville J-M, Tutagata J, Laporte F, Fodjo BK, Mouhamadou CS, Sadia CG, McBeath J, Schmitt F, Horstmann S, Reynaud S, David J-P
Clinical Epigenetics (2021)
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
Herviou L, Ovejero S, Izard F, Karmous-Gadacha O, Gourzones C, Bellanger C, De Smedt E, Ma A, Vincent L, Cartron G, Jin J, De Bruyne E, Grimaud C, Julien E, Moreaux J
Leukemia & Lymphoma (2021)
Angiogenic factors could help us to define patients obtaining complete response with undetectable minimal residual disease in untreated CLL patients treated by FCR: results from the CLL2010FMP, a FILO study
Gagez A-L, Paul F, Alaterre E, Gouilleux-Gruart V, Tuaillon E, Leprêtre S, Ternant D, Letestu R, Moreaux J, Cartron G